BDBM394070 6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[4- (methylsulfonyl)piperazin- 1- yl]cyclohexyl}quinazolin- 4-amine::US9969749, Example 5-20

SMILES CSN1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(F)c(N)c1

InChI Key InChIKey=DSBRUVLBYBDYHG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394070   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394070(US9969749, Example 5-20 | 6-(5-amino-6- fluoropyri...)
Affinity DataIC50: 4nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent