BDBM394170 US9975874, Example 44::cyclopropyl- methyl 4-{3- [1S)-1-{5-[5- chloro-2-(1H- tetrazol-1- yl)phenyl]-1- oxidopyridin- 2-yl}-2- phenylethyl] phenyl} piperidine- 1- carboxylate

SMILES [O-][n+]1cc(ccc1[C@@H](Cc1ccccc1)c1cccc(c1)C1CCN(CC1)C(=O)OCC1CC1)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=DHTIVNKJYPSPLE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394170   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394170(US9975874, Example 44 | cyclopropyl- methyl 4-{3- ...)
Affinity DataIC50: 184nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2020
Entry Details
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