BDBM394192 US9975876, 14::methyl 4-methoxy-2-{[(3R,6R)-6- methyl-1-{[3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl]carbonyl}piperidin-3- yl]oxy}pyridine-3-carboxylate

SMILES COC(=O)c1c(OC)ccnc1O[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cccc(C)c1-n1nccn1

InChI Key InChIKey=QREUTNQVYAMQMW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394192   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394192(US9975876, 14 | methyl 4-methoxy-2-{[(3R,6R)-6- me...)
Affinity DataIC50: 37.9nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394192(US9975876, 14 | methyl 4-methoxy-2-{[(3R,6R)-6- me...)
Affinity DataIC50: 777nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
US Patent