BDBM394197 US9975876, 21::methyl 2-({(3R,6R)-1-[(4-fluoro-2- pyrimidin-2-ylphenyl)carbonyl]-6- methylpiperidin-3-yl}oxy)-4- methoxypyridine-3-carboxylate

SMILES COC(=O)c1c(OC)ccnc1O[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccc(F)cc1-c1ncccn1

InChI Key InChIKey=HVOIBEXSBIRSFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394197   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394197(US9975876, 21 | methyl 2-({(3R,6R)-1-[(4-fluoro-2-...)
Affinity DataIC50: 71.2nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394197(US9975876, 21 | methyl 2-({(3R,6R)-1-[(4-fluoro-2-...)
Affinity DataIC50: 1.47E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
US Patent