BDBM395089 US10308615, Example 100::{2-[(pyridin-3- ylmethyl)amino] pyrimidin-5- yl}(thiophen-2- yl)methanone

SMILES O=C(c1cccs1)c1cnc(NCc2cccnc2)nc1

InChI Key InChIKey=XXQGGYNRNJTVTN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 395089   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395089(US10308615, Example 100 | {2-[(pyridin-3- ylmethyl...)
Affinity DataIC50: 122nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395089(US10308615, Example 100 | {2-[(pyridin-3- ylmethyl...)
Affinity DataIC50: 145nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395089(US10308615, Example 100 | {2-[(pyridin-3- ylmethyl...)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395089(US10308615, Example 100 | {2-[(pyridin-3- ylmethyl...)
Affinity DataIC50: 162nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent