BDBM395475 (R)-1-((2-(2′-chloro-3′-(6-isopropyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridin-2-yl)-2-methylbiphenyl-3-yl)-7-cyanobenzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid::US10308644, Example 87::US10800768, Example 87::US11339149, Example 87::US11596692, Compound P19

SMILES CC(C)N1CCc2cn(nc2C1)-c1cccc(c1Cl)-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C

InChI Key InChIKey=QIHGJDSFONLCBZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 395475   

LigandPNGBDBM395475((R)-1-((2-(2′-chloro-3′-(6-isopropyl-4...)
Affinity DataIC50: 0.550nMAssay Description:Binding assays were conducted in a low volume white 384-well polystyrene plate in a final volume of 20 μL. Compounds to be analyzed were first s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Incyte

US Patent
LigandPNGBDBM395475((R)-1-((2-(2′-chloro-3′-(6-isopropyl-4...)
Affinity DataIC50: 0.550nMAssay Description:Binding assays were conducted in a low volume white 384-well polystyrene plate in a final volume of 20 μL. Compounds to be analyzed were first s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent

LigandPNGBDBM395475((R)-1-((2-(2′-chloro-3′-(6-isopropyl-4...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
US Patent

LigandPNGBDBM395475((R)-1-((2-(2′-chloro-3′-(6-isopropyl-4...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 uL. Inhibitors were first serially diluted in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM395475((R)-1-((2-(2′-chloro-3′-(6-isopropyl-4...)
Affinity DataIC50: 3.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent