BDBM395966 US10308660, Example 42::US12053470, Compound 33

SMILES Cn1c(nc(N)c(Sc2ccnc(N)c2Cl)c1=O)N1CCC2(CC(F)(F)C[C@H]2N)CC1

InChI Key InChIKey=OOZUDBICHRCGIM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395966   

LigandPNGBDBM395966(US10308660, Example 42 | US12053470, Compound 33)
Affinity DataIC50: 14nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM395966(US10308660, Example 42 | US12053470, Compound 33)
Affinity DataIC50: 14nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent