BDBM397110 2-{2-[5-{[2-(2,2- difluorocyclopropyl)phenyl] carbonyl}hexahydropyrrolo[3,4-c] pyrrol-2(1H)-yl]-5-methyl-1,3- oxazol-4-yl}propan-2-ol::US9987255, 24

SMILES Cc1oc(nc1C(C)(C)O)N1CC2CN(CC2C1)C(=O)c1ccccc1C1CC1(F)F

InChI Key InChIKey=SJNMKVCSBNBZGI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397110   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM397110(US9987255, 24 | 2-{2-[5-{[2-(2,2- difluorocyclopro...)
Affinity DataIC50: 22nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM397110(US9987255, 24 | 2-{2-[5-{[2-(2,2- difluorocyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
US Patent