BDBM39781 US20260098044, Example 7

SMILES Cc1c(-c2ccc(F)c(CN3CCCC3)c2)c2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)CC1

InChI Key InChIKey=HXFILMNMRBDVSF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 39781   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 39781BDBM39781(US20260098044, Example 7)
Affinity DataIC50: 75nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 39781BDBM39781(US20260098044, Example 7)
Affinity DataIC50: 200nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2026
Entry Details
US Patent