BDBM398502 (2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-methyl-1H-pyrazol-3-yl)amino]-1-methyl-1H-benzimidazol-6-yl}oxy)cyclohexyl]amino}propan-2-ol::US10323019, Example 6

SMILES COc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)nn1C

InChI Key InChIKey=RUELWUYONKXFSE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 398502   

TargetTyrosine-protein kinase JAK1(Human)
Eli Lilly

US Patent
LigandPNGBDBM398502(US10323019, Example 6 | (2R)-1,1,1-Trifluoro-3-{[c...)
Affinity DataIC50: 5.25nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Eli Lilly

US Patent
LigandPNGBDBM398502(US10323019, Example 6 | (2R)-1,1,1-Trifluoro-3-{[c...)
Affinity DataIC50: 768nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Eli Lilly

US Patent
LigandPNGBDBM398502(US10323019, Example 6 | (2R)-1,1,1-Trifluoro-3-{[c...)
Affinity DataIC50: 2.54E+3nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent