BDBM398504 (2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl-4-(1H-pyrazol-3-ylamino)-1H-benzimidazol-6-yl]oxy}cyclohexyl)amino]propan-2-ol::US10323019, Example 8

SMILES Cn1cnc2c(Nc3cc[nH]n3)cc(O[C@H]3CCC(C)(CC3)NC[C@@H](O)C(F)(F)F)cc12

InChI Key InChIKey=HSCHQSAXLCQGBD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 398504   

TargetTyrosine-protein kinase JAK1(Human)
Eli Lilly

US Patent
LigandPNGBDBM398504(US10323019, Example 8 | (2R)-1,1,1-Trifluoro-3-[(c...)
Affinity DataIC50: 1.91nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Eli Lilly

US Patent
LigandPNGBDBM398504(US10323019, Example 8 | (2R)-1,1,1-Trifluoro-3-[(c...)
Affinity DataIC50: 239nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Eli Lilly

US Patent
LigandPNGBDBM398504(US10323019, Example 8 | (2R)-1,1,1-Trifluoro-3-[(c...)
Affinity DataIC50: 1.17E+3nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent