BDBM398505 (2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)amino]-1-methyl-1H-benzimidazol-6-yl}oxy)cyclohexyl]amino}-1,1-difluoropropan-2-ol::US10323019, Example 9

SMILES Cc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)F)cc3n(C)cnc23)nn1C

InChI Key InChIKey=YFGYUHLLRLZNIL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 398505   

TargetTyrosine-protein kinase JAK1(Human)
Eli Lilly

US Patent
LigandPNGBDBM398505(US10323019, Example 9 | (2R)-3-{[cis-4-({4-[(1,5-D...)
Affinity DataIC50: 5.35nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Eli Lilly

US Patent
LigandPNGBDBM398505(US10323019, Example 9 | (2R)-3-{[cis-4-({4-[(1,5-D...)
Affinity DataIC50: 767nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Eli Lilly

US Patent
LigandPNGBDBM398505(US10323019, Example 9 | (2R)-3-{[cis-4-({4-[(1,5-D...)
Affinity DataIC50: 2.14E+3nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent