BDBM398506 (2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(pyridin-2-yl)-1H-pyrazol-3-yl]amino}-1H-benzimidazol-6-yl)oxy]cyclohexyl}amino)propan-2-ol::US10323019, Example 10

SMILES Cn1cnc2c(Nc3ccn(n3)-c3ccccn3)cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc12

InChI Key InChIKey=HSHRFEDRMXPVSY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 398506   

TargetTyrosine-protein kinase JAK1(Human)
Eli Lilly

US Patent
LigandPNGBDBM398506(US10323019, Example 10 | (2R)-1,1,1-Trifluoro-3-({...)
Affinity DataIC50: 1.49nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Eli Lilly

US Patent
LigandPNGBDBM398506(US10323019, Example 10 | (2R)-1,1,1-Trifluoro-3-({...)
Affinity DataIC50: 220nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Eli Lilly

US Patent
LigandPNGBDBM398506(US10323019, Example 10 | (2R)-1,1,1-Trifluoro-3-({...)
Affinity DataIC50: 660nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent