BDBM398746 1-((3S,4R)-4-(3,5-difluoro- phenyl)-1-(1H-pyrazol-4- yl)pyrrolidin-3-yl)-3-(3,4- dimethyl-1-phenyl-1H-pyrazol- 5-yl)urea::US10323022, Example 223

SMILES Cc1nn(c(NC(=O)N[C@@H]2CN(C[C@H]2c2cc(F)cc(F)c2)c2cn[nH]c2)c1C)-c1ccccc1

InChI Key InChIKey=RITPSBGASBUPCG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398746   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM398746(1-((3S,4R)-4-(3,5-difluoro- phenyl)-1-(1H-pyrazol-...)
Affinity DataIC50: 100nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent