BDBM398754 1-((3R,4S)-4-(3,5- difluorophenyl)-1-(1-methyl-1H- pyrazol-5-yl)pyrrolidin-3-yl)-3- (3-ethoxy-4-methyl-1-phenyl- 1H-pyrazol-5-yl)urea::US10323022, Example 231

SMILES CCOc1nn(c(NC(=O)N[C@H]2CN(C[C@@H]2c2cc(F)cc(F)c2)c2ccnn2C)c1C)-c1ccccc1

InChI Key InChIKey=OHNHSXXWKFYKLL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398754   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM398754(1-((3R,4S)-4-(3,5- difluorophenyl)-1-(1-methyl-1H-...)
Affinity DataIC50: 100nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent