BDBM398767 1-(1',4-dimethyl-1-phenyl- 1H,1'H-[3,4'-bipyrazol]-5-yl)-3- ((3S,4R)-1-(2-methoxypyridin- 3-yl)-4-phenylpyrrolidin-3- yl)urea::US10323022, Example 244

SMILES COc1ncccc1N1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)[C@@H](C1)c1ccccc1

InChI Key InChIKey=JYESMLSRGYJBNN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398767   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM398767(1-(1',4-dimethyl-1-phenyl- 1H,1'H-[3,4'-bipyrazol]...)
Affinity DataIC50: 100nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent