BDBM399921 Azetidin-1-yl[3-(4-chloro-2-methylphenyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl]methanone ::US10323042, Example 1::US10738063, Example 1

SMILES Cc1cc(Cl)ccc1-c1c2OCCCn2nc1C(=O)N1CCC1

InChI Key InChIKey=BLUWLSQGJDRYLP-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 399921   

LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 211nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
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LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 241nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 653nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 2.98E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 2.98E+4nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 241nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 653nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 211nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 211nMAssay Description:Human PDE4B1 coding sequence (amino acids 122 to 736 from the sequence with accession number Q07343) with the mutations resulting in the amino acid s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 241nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 653nMAssay Description:Human PDE4C1 coding sequence (amino acids 2 to 712 from the sequence with accession number NP_000914.2) was cloned into the baculovirus expression ve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM399921(US10323042, Example 1 | Azetidin-1-yl[3-(4-chloro-...)
Affinity DataIC50: 2.98E+4nMAssay Description:A portion of the human PDE4D3 coding sequence (amino acids 50 to 672 from the sequence with accession number Q08499-2) was cloned into the baculoviru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent