BDBM400109 (1aR,6aR)-5-(2-((3-(1H-1,2,3-triazol-4-yl)oxetan-3-yl)amino)-2-oxoacetyl)-N-(3,4-difluorophenyl)-4-methyl-1,1a,6,6a-tetrahydrocyclopropa[b]pyrrolizine-3-carboxamide::US10328053, Compound 87::US10874640, Compound 87

SMILES Cc1c(C(=O)C(=O)NC2(COC2)c2cn(COC(=O)C(C)(C)C)nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(F)c1

InChI Key InChIKey=XHGCWVCYJPJVOE-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 400109   

TargetCapsid protein(HBV-C)
Gilead Sciences

US Patent
LigandPNGBDBM400109(US10328053, Compound 87 | (1aR,6aR)-5-(2-((3-(1H-1...)
Affinity DataEC50:  12.5nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400109(US10328053, Compound 87 | (1aR,6aR)-5-(2-((3-(1H-1...)
Affinity DataEC50:  12.5nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent