BDBM400643 N-[3-[(4aR,7aS)-2-Amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-cyano-pyridine-2-carboxamide hydrochloride::US9999624, 8

SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=VWFFFAAZOKVHQK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 400643   

TargetBeta-secretase 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM400643(N-[3-[(4aR,7aS)-2-Amino-6-(5-fluoropyrimidin-2-yl)...)
Affinity DataIC50: 0.358nMAssay Description:Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20× in KH2PO4 buffer. Ten μL of each dilution ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
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