BDBM400919 2-Amino-N-{4-[(3R,4S,5S)-3-amino-4-hydroxy-4,5-dimethylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide::US10000507, Example 86

SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@](C)(O)[C@H](N)C3)c(N)oc2c1

InChI Key InChIKey=GEHIUHHAAQVTCG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400919   

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM400919(US10000507, Example 86 | 2-Amino-N-{4-[(3R,4S,5S)-...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM400919(US10000507, Example 86 | 2-Amino-N-{4-[(3R,4S,5S)-...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM400919(US10000507, Example 86 | 2-Amino-N-{4-[(3R,4S,5S)-...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent