BDBM400922 2-Amino-N-{5-[(3S)-3-aminopiperidin-1-yl]isothiazol-4-yl}thieno[3,2-b]pyridine-3-carboxamide::US10000507, Example 88

SMILES N[C@H]1CCCN(C1)c1sncc1NC(=O)c1c(N)sc2cccnc12

InChI Key InChIKey=BGESBOZLGOOLBM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400922   

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM400922(US10000507, Example 88 | 2-Amino-N-{5-[(3S)-3-amin...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM400922(US10000507, Example 88 | 2-Amino-N-{5-[(3S)-3-amin...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM400922(US10000507, Example 88 | 2-Amino-N-{5-[(3S)-3-amin...)
Affinity DataIC50: 550nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent