BDBM401921 5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)methoxy]phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile hydrochloride::US10010547, Example 29::US10973817, Example 113

SMILES COc1cc(OCC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

InChI Key InChIKey=XOMSEQMGFZDXTN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 401921   

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandPNGBDBM401921(US10010547, Example 29 | 5-[[5-[2-methoxy-4-[(1-me...)
Affinity DataIC50: 0.0680nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandPNGBDBM401921(US10010547, Example 29 | 5-[[5-[2-methoxy-4-[(1-me...)
Affinity DataIC50: 0.0680nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required cofactors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandPNGBDBM401921(US10010547, Example 29 | 5-[[5-[2-methoxy-4-[(1-me...)
Affinity DataIC50: 0.270nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required cofactors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent