BDBM401938 5-[[5-(2-methoxy-4-piperazin-1-yl-phenyl)-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrilehydrochloride::US10010547, Example 46

SMILES Oc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCNCC1

InChI Key InChIKey=DCOCPWPWGIXMTG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 401938   

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandPNGBDBM401938(US10010547, Example 46 | 5-[[5-(2-methoxy-4-pipera...)
Affinity DataIC50: 0.0540nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent