BDBM402048 N-(2-((4,6-dimethylpyrimidin-2- yl)(methyl)amino)ethyl)-N-ethyl-2- (trifluoromethoxy)benzamide::US10011595, B-7

SMILES CCN(CCN(C)c1nc(C)cc(C)n1)C(=O)c1ccccc1OC(F)(F)F

InChI Key InChIKey=LZJJQGONRPKHMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402048   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402048(US10011595, B-7 | N-(2-((4,6-dimethylpyrimidin-2- ...)
Affinity DataIC50: 9.40nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402048(US10011595, B-7 | N-(2-((4,6-dimethylpyrimidin-2- ...)
Affinity DataIC50: 1.11E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent