BDBM402062 2-(2,2-difluoroethoxy)-N-{2-[(4,6- dimethylpyrimidin-2- yl)(methyl)amino]ethyl}-N- ethylbenzamide::US10011595, B-20

SMILES CCN(CCN(C)c1nc(C)cc(C)n1)C(=O)c1ccccc1OCC(F)F

InChI Key InChIKey=VERXBTJKXAFEKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402062   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402062(US10011595, B-20 | 2-(2,2-difluoroethoxy)-N-{2-[(4...)
Affinity DataIC50: 9.20nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402062(US10011595, B-20 | 2-(2,2-difluoroethoxy)-N-{2-[(4...)
Affinity DataIC50: 1.56E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent