BDBM402068 2-cyclobutyl-N-{2-[(4,6- dimethylpyrimidin-2- yl)(methyl)amino]ethyl}-N- ethylbenzamide::US10011595, B-26

SMILES CCN(CCN(C)c1nc(C)cc(C)n1)C(=O)c1ccccc1C1CCC1

InChI Key InChIKey=NOLGTXNFZRHOLY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402068   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402068(US10011595, B-26 | 2-cyclobutyl-N-{2-[(4,6- dimeth...)
Affinity DataIC50: 20.4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402068(US10011595, B-26 | 2-cyclobutyl-N-{2-[(4,6- dimeth...)
Affinity DataIC50: 1.18E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent