BDBM402135 2-(2,2-difluoroethyl)-N-ethyl- N-(2-((4-(2-hydroxypropan-2- yl)pyrimidin-2- yl)(methyl)amino)ethyl) benzamide::US10011595, H-24

SMILES CCN(CCN(C)c1nccc(n1)C(C)(C)O)C(=O)c1ccccc1CC(F)F

InChI Key InChIKey=YMAWLTYAGRGBNI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402135   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402135(US10011595, H-24 | 2-(2,2-difluoroethyl)-N-ethyl- ...)
Affinity DataIC50: 20.6nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402135(US10011595, H-24 | 2-(2,2-difluoroethyl)-N-ethyl- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent