BDBM402340 6-(3-(2-chloro-4-((5- cyclopropyl-3-(3,5- dichloropyridin-4- yl)isoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-5- fluoronicotinic acid::US10329286, Example 10::US11247986, Example 10

SMILES OC(=O)c1cnc(N2CC(O)(C2)c2ccc(OCc3c(onc3-c3c(Cl)cncc3Cl)C3CC3)cc2Cl)c(F)c1

InChI Key InChIKey=KVJHJSIBAQZAOQ-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 402340   

TargetBile acid receptor [187-472](Human)
Gilead Sciences

US Patent
LigandPNGBDBM402340(US10329286, Example 10 | 6-(3-(2-chloro-4-((5- cyc...)
Affinity DataEC50:  3.40nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetBile acid receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM402340(US10329286, Example 10 | 6-(3-(2-chloro-4-((5- cyc...)
Affinity DataEC50:  3.40nMAssay Description:Expression and purification of the FXR-LBD: An overnight preculture of a transformed E. coli strain was diluted 1:20 in LB-Ampicillin medium and grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetBile acid receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM402340(US10329286, Example 10 | 6-(3-(2-chloro-4-((5- cyc...)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at FXR (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM402340(US10329286, Example 10 | 6-(3-(2-chloro-4-((5- cyc...)
Affinity DataEC50:  6.40nMAssay Description:Agonist activity at FXR (unknown origin) by mammalian one hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed