BDBM404304 2-{5-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)phenyl]carbonyl}- 6-methylpiperidin-3-yl]isoxazol- 3-yl}propan-2-ol::US10017504, 35

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OCC(F)F)c1cc(no1)C(C)(C)O

InChI Key InChIKey=ZARPXHNCLJUNCT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404304   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404304(2-{5-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)phenyl]ca...)
Affinity DataIC50: 140nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404304(2-{5-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)phenyl]ca...)
Affinity DataIC50: 1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent