BDBM404305 2-{5-[(3R,6R)-6-Methyl-1-{[2- (2,2,2-trifluoroethoxy) phenyl]carbonyl} piperidin-3-yl]isoxazol-3- yl}propan-2-ol::US10017504, 36

SMILES CC(C)(O)c1cc(on1)[C@@H]1CCCN(C1)C(=O)c1ccccc1OCC(F)(F)F

InChI Key InChIKey=QJRJGQVLTGZTRF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404305   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404305(2-{5-[(3R,6R)-6-Methyl-1-{[2- (2,2,2-trifluoroetho...)
Affinity DataIC50: 212nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404305(2-{5-[(3R,6R)-6-Methyl-1-{[2- (2,2,2-trifluoroetho...)
Affinity DataIC50: 1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent