BDBM404314 1-(2-{[(2R,5R)-2-Methyl-5-{3-[(1S)- 2,2,2-trifluoro-1-hydroxyethyl]isoxazol- 5-yl}piperidin-1-yl]carbonyl} phenyl)cyclopropanecarbonitrile::US10017504, 45

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1cc(no1)[C@H](O)C(F)(F)F

InChI Key InChIKey=CFVAZBPUVLVBJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404314   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404314(1-(2-{[(2R,5R)-2-Methyl-5-{3-[(1S)- 2,2,2-trifluor...)
Affinity DataIC50: 41.2nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404314(1-(2-{[(2R,5R)-2-Methyl-5-{3-[(1S)- 2,2,2-trifluor...)
Affinity DataIC50: 3.42E+3nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent