BDBM404323 2-{5-[(3R,6R)-6-Methyl-1- {[2-(2H-1,2,3- triazol-2-yl)phenyl] carbonyl}piperidin-3- yl]isoxazol-3-yl}butan-2-ol::US10017504, 54::US10017504, 55

SMILES CCC(C)(O)c1cc(on1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1

InChI Key InChIKey=UTMQUUSZJLGJDB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 404323   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404323(US10017504, 55 | 2-{5-[(3R,6R)-6-Methyl-1- {[2-(2H...)
Affinity DataIC50: 39.8nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404323(US10017504, 55 | 2-{5-[(3R,6R)-6-Methyl-1- {[2-(2H...)
Affinity DataIC50: 76.1nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404323(US10017504, 55 | 2-{5-[(3R,6R)-6-Methyl-1- {[2-(2H...)
Affinity DataIC50: 1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404323(US10017504, 55 | 2-{5-[(3R,6R)-6-Methyl-1- {[2-(2H...)
Affinity DataIC50: 1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent