BDBM404332 2-(3-{(3R,6R)-6-Methyl-1-[(2-pyrimidin-2- ylphenyl)carbonyl]piperidin-3-yl}isothiazol- 5-yl)propan-2-ol::US10017504, 63

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1cc(sn1)C(C)(C)O

InChI Key InChIKey=VHOHJOJHFZPBSX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404332   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404332(2-(3-{(3R,6R)-6-Methyl-1-[(2-pyrimidin-2- ylphenyl...)
Affinity DataIC50: 42.3nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404332(2-(3-{(3R,6R)-6-Methyl-1-[(2-pyrimidin-2- ylphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent