BDBM404338 2-{3-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)pyridin-3-yl]carbonyl}-6- methylpiperidin-3-yl]isothiazol- 5-yl}propan-2-ol::US10017504, 69

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)F)c1cc(sn1)C(C)(C)O

InChI Key InChIKey=XXFKWOLUHIOORO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404338   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404338(2-{3-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)pyridin-3...)
Affinity DataIC50: 42.8nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404338(2-{3-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)pyridin-3...)
Affinity DataIC50: 1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent