BDBM4068 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-6-(thiophen-3-yl)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::2-[4-(2-Diethylaminoethoxy)phenylamino]-8-methyl-6-thiophene-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one deriv. 29

SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccsc4)c(=O)n(C)c3n2)cc1

InChI Key InChIKey=ZBGUTTBTEIGLLQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4068   

TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4068(2-[4-(2-Diethylaminoethoxy)phenylamino]-8-methyl-6...)
Affinity DataIC50: 54nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4068(2-[4-(2-Diethylaminoethoxy)phenylamino]-8-methyl-6...)
Affinity DataIC50: 210nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4068(2-[4-(2-Diethylaminoethoxy)phenylamino]-8-methyl-6...)
Affinity DataIC50: 2.90E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed