BDBM406802 N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine::US10336761, Example 85

SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2)c2cccn2n1

InChI Key InChIKey=XAYJYEKCJLSWSF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 406802   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406802(N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-...)
Affinity DataIC50: 4.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406802(N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406802(N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-...)
Affinity DataIC50: 8.48E+3nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406802(N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of wild type His-tagged TGFbetaR2 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed