BDBM4076 8-Ethyl-6-phenyl-2-(pyridin-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one::8-ethyl-6-phenyl-2-(pyridin-4-ylamino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one deriv. 53

SMILES CCn1c2nc(Nc3ccncc3)ncc2cc(-c2ccccc2)c1=O

InChI Key InChIKey=JMCKXGDSYVEIDE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4076   

TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4076(8-ethyl-6-phenyl-2-(pyridin-4-ylamino)-7H,8H-pyrid...)
Affinity DataIC50: 74nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4076(8-ethyl-6-phenyl-2-(pyridin-4-ylamino)-7H,8H-pyrid...)
Affinity DataIC50: 410nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4076(8-ethyl-6-phenyl-2-(pyridin-4-ylamino)-7H,8H-pyrid...)
Affinity DataIC50: 1.10E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed