BDBM409399 (R/S)-1-Cyclopropyl-2-[6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-::US10377753, Example 274

SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(O)C3CC3)c2c1

InChI Key InChIKey=MHNLSNPERHDYEH-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 409399   

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM409399((R/S)-1-Cyclopropyl-2-[6-(4-fluoro-3-methyl-phenyl...)
Affinity DataIC50: 63.1nMAssay Description:The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409399((R/S)-1-Cyclopropyl-2-[6-(4-fluoro-3-methyl-phenyl...)
Affinity DataKi:  109nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409399((R/S)-1-Cyclopropyl-2-[6-(4-fluoro-3-methyl-phenyl...)
Affinity DataIC50: 182nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed