BDBM412667 US10399979, Compound 1

SMILES COc1cc2c3cnc4[nH]ccc4c3n(CCCN(C)C)c(=O)c2cc1OC

InChI Key InChIKey=NWCQHSKXXCBBMX-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 412667   

TargetTyrosine-protein kinase JAK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataKd:  19nMAssay Description:Binding affinity to JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataKd:  20nMAssay Description:Binding affinity to JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 73nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 73nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 95.6nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 96nMAssay Description:Inhibition of JAK1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 130nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 130nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 427nMAssay Description:Inhibition of TYK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412667(US10399979, Compound 1)
Affinity DataIC50: 427nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent