BDBM4140 (2S,4S)-1-[(2S,3S)-4-(1-benzothiophen-5-yl)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]butanoyl]-N-tert-butyl-4-chloropyrrolidine-2-carboxamide::(3-Hydroxy-2-methylbenzoyl)-2(S)-hydroxy-3(S)-amino-4-(benzo[b]thiophene-5-yl)-butanoyl}-4(S)-Cl-Pro-NH-t-Bu::AHPBA deriv. 25

SMILES Cc1c(O)cccc1C(=O)N[C@@H](Cc1ccc2sccc2c1)[C@H](O)C(=O)N1C[C@@H](Cl)C[C@H]1C(=O)NC(C)(C)C

InChI Key InChIKey=HFMPQLXIHBRKCH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4140   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sankyo

LigandPNGBDBM4140((2S,4S)-1-[(2S,3S)-4-(1-benzothiophen-5-yl)-2-hydr...)
Affinity DataIC50: 1.40nMAssay Description:The inhibitory activities of the compounds toward HIV-1 PR were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2005
Entry Details Article
PubMed