BDBM414103 (R)-7-methyl-4-(1- (methylsulfonyl)piperidin- 4-yl)-6-(1H-pyrazolo- [4,3-b]pyridin-6-yl)- 5,6,7,8-tetrahydro- pyrido[4,3-d]pyrimidine::US10421765, Example 89::US10745420, Example 89

SMILES C[C@@H]1Cc2ncnc(C3CCN(CC3)S(C)(=O)=O)c2CN1c1cnc2cn[nH]c2c1

InChI Key InChIKey=WQNZZBSPIQOTOX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414103   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM414103(US10421765, Example 89 | (R)-7-methyl-4-(1- (methy...)
Affinity DataIC50: 138nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM414103(US10421765, Example 89 | (R)-7-methyl-4-(1- (methy...)
Affinity DataIC50: 138nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent