BDBM414765 5-(4-(Azetidin-1-ylmethyl)- 2-fluoro-6-methylphenyl)-3- (1-methyl-1H-pyrazol-4-yl)- 1H-pyrazolo[3,4-c]pyridine::US10435405, Example 182::US10934288, Example 182
SMILES Cc1cc(CN2CCC2)cc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
InChI Key InChIKey=DWZVSFJBZRFDFR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 414765
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataIC50: 146nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataIC50: 302nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using 7- ethoxyresorufin as substrate by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S mephenytoin as substrate by LC-MS analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataKi: 4.10nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair