BDBM41674 2-(3,4-Dihydro-1H-isoquinolin-2-yl)-7-p-tolyl-7,8-dihydro-6H-quinazolin-5-one::2-(3,4-dihydro-1H-isoquinolin-2-yl)-7-(4-methylphenyl)-7,8-dihydro-6H-quinazolin-5-one::2-(3,4-dihydro-1H-isoquinolin-2-yl)-7-(p-tolyl)-7,8-dihydro-6H-quinazolin-5-one::MLS000557830::SMR000148546::cid_4563710

SMILES Cc1cc2c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(C)cc(N5CCOC[C@@H]5C(F)(F)F)cc4F)C(=O)O)c4cccnc34)c(=O)n(C)c2cn1

InChI Key InChIKey=AEKWYFFLXFCONP-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 41674   

TargetIntegrin alpha-4/beta-7(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 41674BDBM41674(US11116760, Example 425)
Affinity DataEC50:  0.185nMAssay Description:The CHO cell line was cultured in T-175 flasks at 37 degrees C and 95% relative humidity (RH). The growth media consisted of Dulbecco's Modified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
US Patent