BDBM418090 (2R)-2-(6-{5-chloro-2-[(2-ethyl-2H- 1,2,3-triazol-4-yl)amino]pyrimidin-4- yl}-1-oxo-2,3-dihydro-1H-isoindol-2- yl)-N-[(1S)-2-hydroxy-1-(3- methylphenyl)ethyl]propanamide::US10457669, Example 804::US11001575, Example 804

SMILES CCn1ncc(Nc2ncc(Cl)c(n2)-c2ccc3CN([C@H](C)C(=O)N[C@H](CO)c4cccc(C)c4)C(=O)c3c2)n1

InChI Key InChIKey=XRTVQEHXCQZMCL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418090   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418090(US10457669, Example 804 | (2R)-2-(6-{5-chloro-2-[(...)
Affinity DataIC50: 2nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418090(US10457669, Example 804 | (2R)-2-(6-{5-chloro-2-[(...)
Affinity DataIC50: 2nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent