BDBM41819 3-(isopropylthio)-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-yl-5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-(4-morpholinyl)-3-(propan-2-ylthio)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-morpholin-4-yl-3-propan-2-ylsulfanyl-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::MLS000552515::SMR000146030::cid_3790338

SMILES CC(C)Sc1nc(N2CCOCC2)c2CN(C)C(C)(C)Cc2c1C#N

InChI Key InChIKey=VOFFAYCPMVCFGB-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 41819   

TargetImportin subunit alpha-1(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM41819(3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-...)
Affinity DataEC50:  3.93E+4nMAssay Description:Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase PLK1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM41819(3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-...)
Affinity DataIC50: 5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase PLK1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM41819(3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-...)
Affinity DataEC50: >5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase PLK1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM41819(3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-...)
Affinity DataEC50: >5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2011
Entry Details
PCBioAssay