BDBM418264 (2R)-2-(3-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol-4-yl)amino]pyrimidin-4- yl}-5-oxo-5H,6H,7H-pyrrolo[3,4- b]pyridin-6-yl)-N-[(1S)-1-(3-fluoro-5- methoxyphenyl)-2- hydroxyethyl]propanamide::US10457669, Example 1045

SMILES COc1cc(F)cc(n1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ncc(cc2C1=O)-c1nc(Nc2cn(C)nn2)ncc1Cl

InChI Key InChIKey=QIEXGPHMGNNQTF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 418264   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418264(US10457669, Example 1045 | (2R)-2-(3-{5-chloro-2-[...)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent