BDBM42037 4-(1-piperidinyl)-5H-pyrimido[5,4-b]indole::4-piperidin-1-yl-5H-pyrimido[5,4-b]indole::4-piperidino-5H-pyrimid[5,4-b]indole::MLS000027106::SMR000008850::cid_646579

SMILES N1(C=NC=C1)C1=CC=C(C=N1)C#CC=1C=NC(=NC1)N1C[C@@H](N(CC1)C1=NC=CC=N1)COC

InChI Key InChIKey=PHTZFBVQTCNNBO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 42037   

TargetAlpha-synuclein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 42037BDBM42037((R)-5-((6-(1H-imidazol-1-yl)pyridin-3-yl)ethynyl)-...)
Affinity DataKi:  1.10nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
WIPO WO2024186584

TargetAmyloid-beta precursor protein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 42037BDBM42037((R)-5-((6-(1H-imidazol-1-yl)pyridin-3-yl)ethynyl)-...)
Affinity DataKi:  1.20E+4nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
WIPO WO2024186584