BDBM423205 (R)-1-(5-((2-(4-methyl- 1-oxo-1,3-dihydroiso- benzofuran-5-yl)morpho- lino)methyl)pyridin- 2-yl)-1H-imidazole-4- carbonitrile::US10501449, Example 37-I

SMILES Cc1c2COC(=O)c2ccc1[C@@H]1CN(Cc2ccc(nc2)-n2cnc(c2)C#N)CCO1

InChI Key InChIKey=XBDIXGKLIFCJIH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423205   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423205(US10501449, Example 37-I | (R)-1-(5-((2-(4-methyl-...)
Affinity DataIC50: 22nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent