BDBM423208 (R)-1-(5-((3-(4-methyl- 1-oxo-1,3-dihydroiso- benzofuran-5-yl)piper- azin-1-yl)methyl)pyri- din-2-yl)-1H-imidazole- 4-carbonitrile::US10501449, Example 65-I

SMILES Cc1c2COC(=O)c2ccc1[C@@H]1CN(Cc2ccc(nc2)-n2cnc(c2)C#N)CCN1

InChI Key InChIKey=HYAWWCCBOCDGCD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423208   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423208(US10501449, Example 65-I | (R)-1-(5-((3-(4-methyl-...)
Affinity DataIC50: 9.80nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent