BDBM423216 6-(4-(((3R,4R)-4- hydroxy-3-(4- methyl-1-oxo-1,3- dihydroisobenzofur- an-5-yl)piperidin-1- yl)methyl)-1H- pyrazol-1-yl)-2,4- dimethylnicotinonitrile::US10501449, Example 92-I

SMILES COc1cc(nc(C)c1C#N)-n1cc(CN2CC[C@@H](O)[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1

InChI Key InChIKey=VIXHMUOXTWQKRT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423216   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423216(US10501449, Example 92-I | 6-(4-(((3R,4R)-4- hydro...)
Affinity DataIC50: 23nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent